22 Jehovah will smite thee with consumption, and with fever, and with inflammation, and with fiery heat, and with the sword, and with blasting, and with mildew; and they shall pursue thee until thou perish. 23 And thy heaven that is over thy head shall be brass, and the earth that is under thee shall be iron. 24 Jehovah will make the rain of thy land powder and dust: from heaven shall it come down upon thee, until thou be destroyed. 25 Jehovah will cause thee to be smitten before thine enemies; thou shalt go out one way against them, and shalt flee seven ways before them: and thou shalt be tossed to and from among all the kingdoms of the earth. 26 And thy dead body shall be food unto all birds of the heavens, and unto the beasts of the earth; and there shall be none to frighten them away. 27 Jehovah will smite thee with the boil of Egypt, and with the emerods, and with the scurvy, and with the itch, whereof thou canst not be healed. 28 Jehovah will smite thee with madness, and with blindness, and with astonishment of heart; 29 and thou shalt grope at noonday, as the blind gropeth in darkness, and thou shalt not prosper in thy ways: and thou shalt be only oppressed and robbed alway, and there shall be none to save thee. 30 Thou shalt betroth a wife, and another man shall lie with her: thou shalt build a house, and thou shalt not dwell therein: thou shalt plant a vineyard, and shalt not use the fruit thereof. 31 Thine ox shall be slain before thine eyes, and thou shalt not eat thereof: thine ass shall be violently taken away from before thy face, and shall not be restored to thee: thy sheep shall be given unto thine enemies, and thou shalt have none to save thee. 32 Thy sons and thy daughters shall be given unto another people; and thine eyes shall look, and fail with longing for them all the day: and there shall be nought in the power of thy hand. 33 The fruit of thy ground, and all thy labors, shall a nation which thou knowest not eat up; and thou shalt be only oppressed and crushed alway; 34 so that thou shalt be mad for the sight of thine eyes which thou shalt see. 35 Jehovah will smite thee in the knees, and in the legs, with a sore boil, whereof thou canst not be healed, from the sole of thy foot unto the crown of thy head. 36 Jehovah will bring thee, and thy king whom thou shalt set over thee, unto a nation that thou hast not known, thou nor thy fathers; and there shalt thou serve other gods, wood and stone. 37 And thou shalt become an astonishment, a proverb, and a byword, among all the peoples whither Jehovah shall lead thee away. 38 Thou shalt carry much seed out into the field, and shalt gather little in; for the locust shall consume it. 39 Thou shalt plant vineyards and dress them, but thou shalt neither drink of the wine, nor gather [the grapes]; for the worm shall eat them. 40 Thou shalt have olive-trees throughout all thy borders, but thou shalt not anoint thyself with the oil; for thine olive shall cast [its fruit]. 41 Thou shalt beget sons and daughters, but they shall not be thine; for they shall go into captivity. 42 All thy trees and the fruit of thy ground shall the locust possess.

Matthew Henry's Commentary on Deuteronomy 28:22-42

Commentary on Deuteronomy 28:15-44

(Read Deuteronomy 28:15-44)

If we do not keep God's commandments, we not only come short of the blessing promised, but we lay ourselves under the curse, which includes all misery, as the blessing all happiness. Observe the justice of this curse. It is not a curse causeless, or for some light cause. The extent and power of this curse. Wherever the sinner goes, the curse of God follows; wherever he is, it rests upon him. Whatever he has is under a curse. All his enjoyments are made bitter; he cannot take any true comfort in them, for the wrath of God mixes itself with them. Many judgments are here stated, which would be the fruits of the curse, and with which God would punish the people of the Jews, for their apostacy and disobedience. We may observe the fulfilling of these threatenings in their present state. To complete their misery, it is threatened that by these troubles they should be bereaved of all comfort and hope, and left to utter despair. Those who walk by sight, and not by faith, are in danger of losing reason itself, when every thing about them looks frightful.