22 Jehovah will smite thee with consumption, and with fever, and with inflammation, and with burning ague, and with drought, and with blight, and with mildew, and they shall pursue thee until thou perish. 23 And thy heavens which are over thy head shall be brass, and the earth which is under thee, iron. 24 Jehovah will give as the rain of thy land powder and dust; from the heavens shall it come down upon thee until thou be destroyed. 25 Jehovah will give thee up smitten before thine enemies; thou shalt go out against them one way, and by seven ways shalt thou flee before them; and thou shalt be driven hither and thither into all the kingdoms of the earth. 26 And thy carcase shall be meat unto all the fowl of the air, and unto the beasts of the earth, and there shall be no man to scare them away. 27 Jehovah will smite thee with the ulcers of Egypt, and with boils, and with the scab, and with the itch, whereof thou canst not be healed. 28 Jehovah will smite thee with madness, and with blindness, and with astonishment of heart; 29 and thou shalt grope at noonday, as the blind gropeth in darkness, and thou shalt not prosper in thy ways; and thou shalt be only oppressed and spoiled continually, and there shall be none to save. 30 Thou shalt betroth a wife, and another man shall lie with her; thou shalt build a house, and thou shalt not dwell therein; thou shalt plant a vineyard, and shalt not eat of it. 31 Thine ox shall be slaughtered before thine eyes, and thou shalt not eat thereof; thine ass shall be snatched away from before thy face, and shall not return to thee; thy sheep shall be given unto thine enemies, and thou shalt have none to recover them. 32 Thy sons and thy daughters shall be given unto another people, and thine eyes shall look, and languish for them all the day long; and there shall be no power in thy hand [to help it]. 33 The fruit of thy ground and all thy labour, shall a people that thou knowest not eat up; and thou shalt be only oppressed and crushed continually. 34 And thou shalt be mad through the sight of thine eyes which thou shalt see. 35 Jehovah will smite thee in the knees and in the legs with evil ulcers, whereof thou canst not be healed, from the sole of thy foot unto the top of thy head. 36 Jehovah will bring thee, and thy king whom thou shalt set over thee, unto a nation that neither thou nor thy fathers have known, and there shalt thou serve other gods, wood and stone. 37 And thou shalt become an astonishment, a proverb, and a byword, among all the peoples whither Jehovah shall lead thee. 38 Thou shalt carry much seed out into the field, and shalt gather little in; for the locust shall devour it. 39 Thou shalt plant and till vineyards, but shalt drink no wine, nor gather [the fruit]; for the worms shall eat it. 40 Olive-trees shalt thou have throughout all thy borders, but thou shalt not anoint thyself with oil; for thine olive-tree shall cast its fruit. 41 Sons and daughters shalt thou beget, but thou shalt not have them [to be with thee]; for they shall go into captivity. 42 All thy trees and the fruit of thy ground shall the locust possess.

Matthew Henry's Commentary on Deuteronomy 28:22-42

Commentary on Deuteronomy 28:15-44

(Read Deuteronomy 28:15-44)

If we do not keep God's commandments, we not only come short of the blessing promised, but we lay ourselves under the curse, which includes all misery, as the blessing all happiness. Observe the justice of this curse. It is not a curse causeless, or for some light cause. The extent and power of this curse. Wherever the sinner goes, the curse of God follows; wherever he is, it rests upon him. Whatever he has is under a curse. All his enjoyments are made bitter; he cannot take any true comfort in them, for the wrath of God mixes itself with them. Many judgments are here stated, which would be the fruits of the curse, and with which God would punish the people of the Jews, for their apostacy and disobedience. We may observe the fulfilling of these threatenings in their present state. To complete their misery, it is threatened that by these troubles they should be bereaved of all comfort and hope, and left to utter despair. Those who walk by sight, and not by faith, are in danger of losing reason itself, when every thing about them looks frightful.