22 God will set consumption and fever and rash and seizures and dehydration and blight and jaundice on you. They'll hunt you down until they kill you. 23 The sky over your head will become an iron roof, the ground under your feet, a slab of concrete. 24 From out of the skies God will rain ash and dust down on you until you suffocate. 25 God will defeat you by enemy attack. You'll come at your enemies on one road and run away on seven roads. All the kingdoms of Earth will see you as a horror. 26 Carrion birds and animals will boldly feast on your dead body with no one to chase them away. 27 God will hit you hard with the boils of Egypt, hemorrhoids, scabs, and an incurable itch. 28 He'll make you go crazy and blind and senile. 29 You'll grope around in the middle of the day like a blind person feeling his way through a lifetime of darkness; you'll never get to where you're going. Not a day will go by that you're not abused and robbed. And no one is going to help you. 30 You'll get engaged to a woman and another man will take her for his mistress; you'll build a house and never live in it; you'll plant a garden and never eat so much as a carrot; 31 you'll watch your ox get butchered and not get a single steak from it; your donkey will be stolen from in front of you and you'll never see it again; your sheep will be sent off to your enemies and no one will lift a hand to help you. 32 Your sons and daughters will be shipped off to foreigners; you'll wear your eyes out looking vainly for them, helpless to do a thing. 33 Your crops and everything you work for will be eaten and used by foreigners; you'll spend the rest of your lives abused and knocked around. 34 What you see will drive you crazy. 35 God will hit you with painful boils on your knees and legs and no healing or relief from head to foot. 36 God will lead you and the king you set over you to a country neither you nor your ancestors have heard of; there you'll worship other gods, no-gods of wood and stone. 37 Among all the peoples where God will take you, you'll be treated as a lesson or a proverb - a horror! 38 You'll plant sacks and sacks of seed in the field but get almost nothing - the grasshoppers will devour it. 39 You'll plant and hoe and prune vineyards but won't drink or put up any wine - the worms will devour them. 40 You'll have groves of olive trees everywhere, but you'll have no oil to rub on your face or hands - the olives will have fallen off. 41 You'll have sons and daughters but they won't be yours for long - they'll go off to captivity. 42 Locusts will take over all your trees and crops.

Matthew Henry's Commentary on Deuteronomy 28:22-42

Commentary on Deuteronomy 28:15-44

(Read Deuteronomy 28:15-44)

If we do not keep God's commandments, we not only come short of the blessing promised, but we lay ourselves under the curse, which includes all misery, as the blessing all happiness. Observe the justice of this curse. It is not a curse causeless, or for some light cause. The extent and power of this curse. Wherever the sinner goes, the curse of God follows; wherever he is, it rests upon him. Whatever he has is under a curse. All his enjoyments are made bitter; he cannot take any true comfort in them, for the wrath of God mixes itself with them. Many judgments are here stated, which would be the fruits of the curse, and with which God would punish the people of the Jews, for their apostacy and disobedience. We may observe the fulfilling of these threatenings in their present state. To complete their misery, it is threatened that by these troubles they should be bereaved of all comfort and hope, and left to utter despair. Those who walk by sight, and not by faith, are in danger of losing reason itself, when every thing about them looks frightful.