2 But your iniquities have separated between you and your God, and your sins have hid  his face from you, that he will not hear.
2 But your iniquities have separated you from your God; your sins have hidden his face from you, so that he will not hear.
2 but your iniquities have made a separation between you and your God, and your sins have hidden his face from you so that he does not hear.
2 There's nothing wrong with God; the wrong is in you. Your wrongheaded lives caused the split between you and God. Your sins got between you so that he doesn't hear.
2 But your iniquities have separated you from your God; And your sins have hidden His face from you, So that He will not hear.
2 It's your sins that have cut you off from God. Because of your sins, he has turned away and will not listen anymore.
Matthew Henry's Commentary on Isaiah 59:2
Commentary on Isaiah 59:1-8
(Read Isaiah 59:1-8)
If our prayers are not answered, and the salvation we wait for is not wrought for us, it is not because God is weary of hearing prayer, but because we are weary of praying. See here sin in true colours, exceedingly sinful; and see sin in its consequences, exceedingly hurtful, separating from God, and so separating us, not only from all good, but to all evil. Yet numbers feed, to their own destruction, on infidel and wicked systems. Nor can their skill or craft, in devising schemes, as the spider weaves its web, deliver or save them. No schemes of self-wrought salvation shall avail those who despise the Redeemer's robe of righteousness. Every man who is destitute of the Spirit of Christ, runs swiftly to evil of some sort; but those regardless of Divine truth and justice, are strangers to peace.