11 And they said evil things against the God of heaven because of their pain and their wounds; and they were not turned from their evil works.

12 And the sixth let what was in his vessel come out on the great river Euphrates; and it became dry, so that the way might be made ready for the kings from the east. 13 And I saw coming out of the mouth of the dragon, and out of the mouth of the beast, and out of the mouth of the false prophet, three unclean spirits, like frogs. 14 For they are evil spirits, working signs; who go out even to the kings of all the earth, to get them together to the war of the great day of God, the Ruler of all. 15 (See, I come as a thief. Happy is he who is watching and keeps his robes, so that he may not go unclothed, and his shame be seen.) 16 And they got them together into the place which is named in Hebrew Armageddon.

17 And the seventh let what was in his vessel come out on the air; and there came out a great voice from the house of God, from the high seat, saying, It is done. 18 And there were flames and voices and thunders; and there was a great earth-shock so that never, from the time when men were on the earth, had there been so great an earth-shock, so full of power.

Matthew Henry's Commentary on Revelation 16:11-18

Commentary on Revelation 16:8-11

(Read Revelation 16:8-11)

The heart of man is so desperately wicked, that the most severe miseries never will bring any to repent, without the special grace of God. Hell itself is filled with blasphemies; and those are ignorant of the history of human nature, of the Bible, and of their own hearts, who do not know that the more men suffer, and the more plainly they see the hand of God in their sufferings, the more furiously they often rage against him. Let sinners now seek repentance from Christ, and the grace of the Holy Spirit, or they will have the anguish and horror of an unhumbled, impenitent, and desperate heart; thus adding to their guilt and misery through all eternity. Darkness is opposed to wisdom and knowledge, and forebodes the confusion and folly of the idolaters and followers of the beast. It is opposed to pleasure and joy, and signifies anguish and vexation of spirit.

Commentary on Revelation 16:12-16

(Read Revelation 16:12-16)

This probably shows the destruction of the Turkish power, and of idolatry, and that a way will be made for the return of the Jews. Or, take it for Rome, as mystical Babylon, the name of Babylon being put for Rome, which was meant, but was not then to be directly named. When Rome is destroyed, her river and merchandise must suffer with her. And perhaps a way will be opened for the eastern nations to come into the church of Christ. The great dragon will collect all his forces, to make one desperate struggle before all be lost. God warns of this great trial, to engage his people to prepare for it. These will be times of great temptation; therefore Christ, by his apostle, calls on his professed servants to expect his sudden coming, and to watch that they might not be put to shame, as apostates or hypocrites. However Christians differ, as to their views of the times and seasons of events yet to be brought to pass, on this one point all are agreed, Jesus Christ, the Lord of glory, will suddenly come again to judge the world. To those living near to Christ, it is an object of joyful hope and expectation, and delay is not desired by them.

Commentary on Revelation 16:17-21

(Read Revelation 16:17-21)

The seventh and last angel poured forth his vial, and the downfal of Babylon was finished. The church triumphant in heaven saw it and rejoiced; the church in conflict on earth saw it and became triumphant. God remembered the great and wicked city; though for some time he seemed to have forgotten her idolatry and cruelty. All that was most secure was carried away by the ruin. Men blasphemed: the greatest judgments that can befal men, will not bring to repentance without the grace of God. To be hardened against God, by his righteous judgments, is a certain token of sure and utter destruction.