19 Lamech married two women. The first was named Adah, and the second was Zillah. 20 Adah gave birth to Jabal, who was the first of those who raise livestock and live in tents. 21 His brother's name was Jubal, the first of all who play the harp and flute. 22 Lamech's other wife, Zillah, gave birth to a son named Tubal-cain. He became an expert in forging tools of bronze and iron. Tubal-cain had a sister named Naamah.

23 One day Lamech said to his wives, "Adah and Zillah, hear my voice; listen to me, you wives of Lamech. I have killed a man who attacked me, a young man who wounded me. 24 If someone who kills Cain is punished seven times, then the one who kills me will be punished seventy-seven times!"

25 Adam had sexual relations with his wife again, and she gave birth to another son. She named him Seth, for she said, "God has granted me another son in place of Abel, whom Cain killed." 26 When Seth grew up, he had a son and named him Enosh. At that time people first began to worship the Lord by name.

Matthew Henry's Commentary on Genesis 4:19-28

Commentary on Genesis 4:19-24

(Read Genesis 4:19-24)

One of Cain's wicked race is the first recorded, as having broken the law of marriage. Hitherto, one man had but one wife at a time; but Lamech took two. Wordly things, are the only things that carnal, wicked people set their hearts upon, and are most clever and industrious about. So it was with this race of Cain. Here was a father of shepherds, and a father of musicians, but not a father of the faithful. Here is one to teach about brass and iron, but none to teach the good knowledge of the Lord: here are devices how to be rich, and how to be mighty, and how to be merry; but nothing of God, of his fear and service. Present things fill the heads of most. Lamech had enemies, whom he had provoked. He draws a comparison betwixt himself and his ancestor Cain; and flatters himself that he is much less criminal. He seems to abuse the patience of God in sparing Cain, into an encouragement to expect that he may sin unpunished.

Commentary on Genesis 4:25-26

(Read Genesis 4:25-26)

Our first parents were comforted in their affliction by the birth of a son, whom they called Seth, that is, 'set,' 'settled,' or 'placed;' in his seed mankind should continue to the end of time, and from him the Messiah should descend. While Cain, the head of the apostacy, is made a wanderer, Seth, from whom the true church was to come, is one fixed. In Christ and his church is the only true settlement. Seth walked in the steps of his martyred brother Abel; he was a partaker of like precious faith in the righteousness of our God and Saviour Jesus Christ, and so became a fresh witness of the grace and influence of God the Holy Spirit. God gave Adam and Eve to see the revival of religion in their family. The worshippers of God began to do more in religion; some, by an open profession of true religion, protested against the wickedness of the world around. The worse others are, the better we should be, and the more zealous. Then began the distinction between professors and profane, which has been kept up ever since, and will be, while the world stands.