4 A wicked and adulterous generation seeks after a sign, and a sign shall not be given to it save the sign of Jonas. And he left them and went away.

The Leaven of the Pharisees and Sadducees

5 And when his disciples were come to the other side, they had forgotten to take bread. 6 And Jesus said to them, See and beware of the leaven of the Pharisees and Sadducees. 7 And they reasoned among themselves, saying, Because we have taken no bread. 8 And Jesus knowing [it], said, Why reason ye among yourselves, O ye of little faith, because ye have taken no bread? 9 Do ye not yet understand nor remember the five loaves of the five thousand, and how many hand-baskets ye took [up]? 10 nor the seven loaves of the four thousand, and how many baskets ye took [up]?

Matthew Henry's Commentary on Matthew 16:4-10

Commentary on Matthew 16:1-4

(Read Matthew 16:1-4)

The Pharisees and Sadducees were opposed to each other in principles and in conduct; yet they joined against Christ. But they desired a sign of their own choosing: they despised those signs which relieved the necessity of the sick and sorrowful, and called for something else which would gratify the curiosity of the proud. It is great hypocrisy, when we slight the signs of God's ordaining, to seek for signs of our own devising.

Commentary on Matthew 16:5-12

(Read Matthew 16:5-12)

Christ speaks of spiritual things under a similitude, and the disciples misunderstand him of carnal things. He took it ill that they should think him as thoughtful about bread as they were; that they should be so little acquainted with his way of preaching. Then understood they what he meant. Christ teaches by the Spirit of wisdom in the heart, opening the understanding to the Spirit of revelation in the word.