17 See, I am stirring up the Medes against them, who have no regard for silver and do not delight in gold. 18 Their bows will slaughter the young men; they will have no mercy on the fruit of the womb; their eyes will not pity children.

19 And Babylon, the glory of kingdoms, the splendor and pride of the Chaldeans, will be like Sodom and Gomorrah when God overthrew them. 20 It will never be inhabited or lived in for all generations; Arabs will not pitch their tents there, shepherds will not make their flocks lie down there.

Matthew Henry's Commentary on Isaiah 13:17-20

Commentary on Isaiah 13:6-18

(Read Isaiah 13:6-18)

We have here the terrible desolation of Babylon by the Medes and Persians. Those who in the day of their peace were proud, and haughty, and terrible, are quite dispirited when trouble comes. Their faces shall be scorched with the flame. All comfort and hope shall fail. The stars of heaven shall not give their light, the sun shall be darkened. Such expressions are often employed by the prophets, to describe the convulsions of governments. God will visit them for their iniquity, particularly the sin of pride, which brings men low. There shall be a general scene of horror. Those who join themselves to Babylon, must expect to share her plagues, Revelation 18:4. All that men have, they would give for their lives, but no man's riches shall be the ransom of his life. Pause here and wonder that men should be thus cruel and inhuman, and see how corrupt the nature of man is become. And that little infants thus suffer, which shows that there is an original guilt, by which life is forfeited as soon as it is begun. The day of the Lord will, indeed, be terrible with wrath and fierce anger, far beyond all here stated. Nor will there be any place for the sinner to flee to, or attempt an escape. But few act as though they believed these things.

Commentary on Isaiah 13:19-22

(Read Isaiah 13:19-22)

Babylon was a noble city; yet it should be wholly destroyed. None shall dwell there. It shall be a haunt for wild beasts. All this is fulfilled. The fate of this proud city is a proof of the truth of the Bible, and an emblem of the approaching ruin of the New Testament Babylon; a warning to sinners to flee from the wrath to come, and it encourages believers to expect victory over every enemy of their souls, and of the church of God. The whole world changes and is liable to decay. Wherefore let us give diligence to obtain a kingdom which cannot be moved; and in this hope let us hold fast that grace whereby we may serve God acceptably with reverence and godly fear.